2009 – Receptors on epithelial cells are implicated in the development and exacerbation of asthma
This research furthers the investigation into the involvement of one of the 4 protease-activated receptor (PAR2) expressed on airway epithelial cells. PAR2 is known to respond to house dust mite allergen Der p1 and trigger a cascade of cytokine release. Thymic stromal lymphopoietin (TSLP) is produced by epithelia cells and triggers dendritic cell-medicated Th2 type inflammation. The paper demonstrates that TSLP expression is induced in airway epithelial cells by exposure to allergen-derived proteases and that PAR 2 is involved in the process. By promoting TSLP production in the airways, proteases associated allergens may facilitate the development and/or exacerbation of Th2-type airway inflammation, particularly in allergic individuals.
‘Proteases Induce Production of Thymic Stromal Lymphopoietin [TSLP] by Airway Epithelial Cells through Protease-Activated Receptor -21 [PAR 2]’, Hideake Kouzaki , Scott M. O’Grady, Christopher B Lawrence, Hirohitl Kita. J. Immunol. 2009; 183:1427-1434
Similar pages
- Lung cells in asthma – protectors or drivers of disease.
- 2006 – Foetal airway structure can be affected by the environment
- Th17 cells: a new T Lymphocyte and its roll in asthma.
- 2009 – ‘Dust Mites’, a major new publication by Dr. Matthew Collof
- 2005 – Increased levels of indoor mould are blamed for the development and persistence of asthma in adults
House dust mites must have a still, dark and warm and damp environment. Take away any of these and they die
